The megakaryocytes in idiopathic thrombocytopenic purpura, a form of hypersplenism.

An adult girl, robust, without manifest cause, was attacked recently, towards the period of her menses, with a sudden severe hemorrhage from the nose, with bright but foul blood escaping together with a bloody vomiting of a very thick extremely black blood. Immediately there appeared about the neck and on the arms, spots partly black, partly violaceous or purple, such as are often seen in malignant smallpox moreover the number of the spots increasing and surrounding completely both of the eyes, the back of the nose and the skin around the mouth and chin, with a livid black color, like marked from bruises.